JOURNAL OF ANIMAL SCIENCE AND VETERINARY MEDICINE
Integrity Research Journals
ISSN: 2536-7099
Model: Open Access/Peer Reviewed
DOI: 10.31248/JASVM
Start Year: 2016
Email: jasvm@integrityresjournals.org
Comparative effects of Vitamin E and garlic oil supplementation on oxidative stress, hepatic and renal in weaner rabbits
https://doi.org/10.31248/JASVM2026.654 | Article Number: 2595BA8311 | Vol.11 (2) - April 2026
Received Date: 02 April 2026 | Accepted Date: 28 April 2026 | Published Date: 30 April 2026
Authors: Diri, M.* and Saturday, L.
Keywords: Alanine amino transferase, catalase, glutathione, aspartic amino transferase, blood urea nitrogen, and superoxide dismutase.
This study evaluated the comparative effects of vitamin E and garlic oil supplementation on oxidative stress markers, hepatic, and renal functions in weaner rabbits. Twenty-four male rabbits (5 weeks old) were used. Prior to the experiment, the housing was disinfected with hypochlorite solution and left to dry for a week before introducing the rabbits into the house. Following a two-week acclimatization period, the rabbits were randomly assigned to three treatment groups (n = 8) in a Completely Randomized Design: T1 (control), T2 (vitamin E at 300 mg/kg body weight), and T3 (garlic oil at 300 mg/kg body weight). Treatments were administered orally for four weeks, and all rabbits were fed commercial grower's mash ad libitum. Oxidative stress biomarkers assessed included glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA). Liver and kidney function indices measured were alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), blood urea nitrogen (BUN), and creatinine. Results revealed significant differences (p<0.05) among treatments. GSH levels were significantly higher in T2 and T3 compared to T1, with no difference between T2 and T3. GSH-Px, CAT, SOD, and MDA differed significantly across all groups. Vitamin E exhibited superior antioxidant effects, including greater reduction in MDA. However, garlic oil showed better improvement in hepatic and renal parameters, recording lower ALT, AST, ALP, BUN, and creatinine values. In conclusion, both vitamin E and garlic oil enhanced antioxidant status and reduced oxidative stress in weaner rabbits. Vitamin E demonstrated stronger antioxidant capacity, while garlic oil was more effective in supporting liver and kidney functions.
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