RESEARCH JOURNAL OF FOOD SCIENCE AND NUTRITION
Integrity Research Journals
ISSN: 2536-7080
Model: Open Access/Peer Reviewed
DOI: 10.31248/RJFSN
Start Year: 2016
Email: rjfsn@integrityresjournals.org
Effect of Bambara groundnut (Vigna subterranea) consumption on biomarkers of oxidative stress in alloxan- induced diabetic Wistar rats
https://doi.org/10.31248/RJFSN2019.066 | Article Number: 8DC6ED971 | Vol.4 (3) - June 2019
Received Date: 12 February 2019 | Accepted Date: 29 April 2019 | Published Date: 30 June 2019
Authors: Olanipekun, O. T. , Omenna, E. C.* , Adeniyi, G. A. and Adedeji, F. T.
Keywords: oxidative stress, Alanine amino transferase, alkaline phosphatase, aspartate transaminase, Bambara groundnut, diabetic rats, oxidative stress biomarkers.
This study investigated the effect of consumption of diet supplemented with Bambara-groundnut (BGN) on some biomarkers of oxidative stress in diabetic induced rats. A total of 24 apparently healthy adult albino wistar rats were assembled and divided into 4 groups A-D; group A (Non diabetic rats, fed on normal diet), B (Diabetic rats fed on normal diet), C (Diabetic rats fed on 10% Bambara-groundnut diet), D (Diabetic rats fed on Nitrogen free diet) with each group consisting of 6 rats respectively. After 4 weeks of feeding, rats were sacrificed and blood collected into heparin container and used for laboratory analysis. Superoxide dismutase (SOD), glutathione peroxidase (GSHPER), alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate transaminase (AST) were assayed for using standard laboratory methods. The result showed that Group C rats had the lowest post-feeding glucose concentration (75 mg/dl). AST, ALT, and ALP were elevated in diabetic induced rats; but, treatment with Bambara-groundnut diet reversed the parameters close to control. The highest levels of SOD and GSHPER were found in group C rats while the group B rats had the highest oxidative stress. It can be concluded that Bambara-groundnut diet modulated and ameliorated the oxidative stress in diabetic rats.
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